Hot sale 99.9% high-purity white powder GW0724 is used to gain muscle and reduce fat CAS 317318-84-6

Short Description:

Product name: GW0742

CAS No: 317318-84-6

Molecular formula: C21H17F4NO3S2

Molecular weight: 471.49

EINECS No: 1532714-185-1

Melting point: 134.5-135.5 ° C

Boiling point: 591.5 ± 60.0 ° C (Predicted)

Density: 1.46 ± 0.1g/cm3 (Predicted) Chemicalbook

Storage condition: 2-8 ° C

Solubility: DMSO:>5mg/mL

Form: solid

Acidity coefficient: (pKa) 3.17 ± 0.10 (Predicted)

Color: white

Purity: >98%

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Product Detail

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Product introduction

One can activate PPAR β 's PPAR β Ligands. It is reported that it can increase the expression of interleukin (IL) - 6 and IL - 8.

Purpose

GW0742 is a human peroxisome proliferator-activated receptor δ （PPAR δ） Small molecule agonist. It shows that for PPAR δ Its EC50 is 1.1 nM, and its selectivity is 100 times that of other human subtypes.

In vitro study

In the basic cell transcription experiment, GW0742 effectively acts on hPPAR α， hPPAR γ， And hPPAR δ， EC50 is 1.1 respectively μ M,2 μ M and 1nM. GW0742(0.2 μ M and 1 μ M) Effected on N/TERT-1 keratinocytes, significantly increased PPAR β/δ Activity. GW0742(1 μ M) It significantly inhibited the average cell number of N/TERT-1 keratinocytes. GW0742(1 μ M) Increase the number of G1 phase cells and reduce the number of S phase cells. GW0742(1 μ M) Effected on N/TERT-1 keratinocytes and mouse primary keratinocytes, significantly increased mRNA encoded ADRP, a PPAR β/δ Target gene of. GW0742(1 μ M) Acting on N/TERT-1 cells, the phosphorylation of retinoblastoma (Rb) and the level of p42/44ERK were significantly reduced. one hundred μ MGW0742 acts on cerebellar granule neurons, significantly reducing neuronal cell death induced by low KCl. Observe Chemicalbook to 100 by measuring LDH release μ MGW0742 significantly enhanced cell death. one hundred μ MGW0742 treated cerebellar granule neuron culture medium for 6 hours, significantly enhanced the expression of c-Jun. one hundred μ MGW0742 acts on MCF-7 cells and increases PPAR in the presence of 1.5% BSA α Mediated transcription.

In vivo study

GW0742 (10mg/kg) treated C57BL6/J mice promoted reverse cholesterol transport. GW0742 (10mg/kg) treatment of C57BL6/J mice promoted the excretion of high-density lipoprotein cholesterol in the stool, although it had no effect on the metabolism of high-density lipoprotein cholesterol. GW0742 acts on the small intestine of mice and reduces the expression of NPC1L1 mRNA. GW0742 (30mg/kg) treatment of male BALB/c mice significantly reduced leukocyte recruitment into lung space before inducing LPS-mediated lung inflammation. GW0742 (30mg/kg) treatment of bronchoalveolar lavage fluid in mice significantly reduced the proinflammatory cytokines IL-6 and IL-1 β And TNF- α Protein and mRNA levels.

Characteristic

GW0742 and L-165041 both activate PPAR in platelets β, Not PPAR γ Or PPAR α

Storage conditions

3 years - 20 ° C powder
1 year - 80 ° C soluble in solvent

First aid measures

Description of necessary first aid measures
1. Inhalation
If inhaled, move the patient to fresh air. If you stop breathing, give artificial respiration.
2. Skin contact
Wash with soap and plenty of water.
3. Eye contact
Rinse eyes with water as a precaution.
4. Ingestion
Never feed anything from the mouth to the unconscious. Rinse your mouth with water.

Main symptoms and effects, acute and delayed effects

Instructions and instructions for timely medical treatment and special treatment required.

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